#bluejc transcript

Healthcare Social Media Transcript

From: Mon Oct 14 0:00:00 PDT 2013
To: Mon Oct 21 0:00:00 PDT 2013

What is #bluejc? Who were the influencers during this time period? #bluejc analytics


Healthcare Conference  - Healthcare Tweet Chats  -  Healthcare Analytics

maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
Next #BlueJC 1830 this evening..lots to discuss! Join us then.
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
Next #BlueJC tonight 18030 GMT. See http://t.co/4sSVNng8hf Lots to discuss!
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
Next #BlueJC tonight 1830 GMT. See http://t.co/4sSVNng8hf for the paper on prediction of pre-eclampsia. Lots to discuss!
jdaru
https://pbs.twimg.com/profile_images/2874320195/630e8f5717efdf7639550a7fe7a286ae_normal.jpeg
RT @elaineleung: RT @ObsGynStudies: Monday 14th: BJOG Journal Club on predicting preterm pre-eclampsia in nulliparous women. http://t.co/hf
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
RT @maireadblack: Next #BlueJC tonight 1830 GMT. See http://t.co/4sSVNng8hf for the paper on prediction of pre-eclampsia. Lots to discuss!
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
RT @RCObsGyn: Next #BlueJC TODAY!18.30 BST Predicting preterm preeclampsia:  http://t.co/iW8NBCaLq4 Discussion pts: http://t.co/rbq8agySae
bjogtweets
https://pbs.twimg.com/profile_images/1268715644/cover_normal.JPG
RT @maireadblack: Next #BlueJC tonight 1830 GMT. See http://t.co/4sSVNng8hf for the paper on prediction of pre-eclampsia. Lots to discuss!
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
Only 1 hour to go. RT @BJOGTweets: Next #BlueJC tonight 1830 GMT. http://t.co/hfjJ7PtN52 for the paper on prediction of pre-eclampsia.
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
You may want to read this before #BlueJC MT @jimgthornton: SCOPE rsrchrs have responded! http://t.co/TC9HrfaMrJ
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
@greenjrnl Only 25mins to go. RT @BJOGTweets: #BlueJC tonight 1830 BST. http://t.co/hfjJ7PtN52 for the paper on prediction of #preeclampsia.
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
Join us at #BlueJC in 5 minutes. Link to discussion paper bit.ly.GGP04M
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
Join us at #BlueJC in 5 minutes. Link to discussion paper http://t.co/dfg3FQQQVQ
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
Welcome to #BlueJC! Today’s paper from SCOPE illustrates their aim to ‘predict and prevent’ PET, SGA and spont PTL through prospective work
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
#BlueJC paper; clinical, angiogenic and US risk factors for PET are assessed for best combination to predict PET + delivery by 37/40
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
Prediction test accuracy is compared to current NICE clinical risk assessment tool (applied to theoretical low-risk nullip populatn) #BlueJC
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
.@maireadblack Hello! Thanks for hosting #BlueJC
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
.@maireadblack I think the broad aim of SCOPE is really interesting. http://t.co/qKfRE0BeGw #BlueJC
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
@elaineleung Very interesting and good illustration of collaboration #BlueJC
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
.@BJOGTweets- If anyone is interested to join #BlueJC- please make sure you include the hashtag "BlueJC" in your tweets
jimgthornton
https://pbs.twimg.com/profile_images/1677440749/EURO_Jim_Thornton_normal.JPG
@elaineleung @maireadblack #bluejc agree. Am i correct in assuming this is main report for SCOPE preeclampsia prediction?
gynaeresearcher
https://pbs.twimg.com/profile_images/2350090781/matisse_normal.jpg
Hello all at #BlueJC. What have I missed? @elaineleung @Profkkhan
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
I thought so- until I read yr blog! MT @jimgthornton: #bluejc Am i correct in assuming this is main report 4 SCOPE preeclampsia prediction?
jimgthornton
https://pbs.twimg.com/profile_images/1677440749/EURO_Jim_Thornton_normal.JPG
@elaineleung @maireadblack #bluejc It's testing the three most wellstudied markers. plGF, S-flt, and the other one.
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
@GynaeResearcher Just started #BlueJC! Talking about What SCOPE encompasses!
eichelbergerk
https://abs.twimg.com/sticky/default_profile_images/default_profile_5_normal.png
@elaineleung @maireadbloack @jimgthornton #bluejc Curious if these 3 biomarkers were selected a priori for this analysis?
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
.@jimgthornton Endoglin- http://t.co/cx1hLVtx0x #BlueJC
jdaru
https://pbs.twimg.com/profile_images/2874320195/630e8f5717efdf7639550a7fe7a286ae_normal.jpeg
@elaineleung @jimgthornton I assumed the primary outcome was to determine markers to predict pre eclampsia #BlueJC
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
We are discussing the #BlueJC Myers paper..
eichelbergerk
https://abs.twimg.com/sticky/default_profile_images/default_profile_5_normal.png
@elaineleung @maireadblack #bluejc @jimgthornton Amazing how consistent the AUCs are for these biomarker prediction studies. All 0.80-0.85!
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
.@jimgthornton Paul Sheard from Alere: "data from a pilot case-cohort study" #BlueJC http://t.co/s9WYKjEpCh
jimgthornton
https://pbs.twimg.com/profile_images/1677440749/EURO_Jim_Thornton_normal.JPG
#bluejc If u've not read blog. I'm critical of authors for changing 1ry endpoint from all PE to PE<37 weeks betwn registration and public.
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
Let's address @jimgthornton's question "Where is the main report?" later. I think we should stick to the #BlueJC guide for a moment!
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
.@EichelbergerK You seem to know a bit about AUCs interpretation- is it surprising that it's consistent? What does it mean? #bluejc
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
@jimthornton Good example of why prospective registration of all variables to be studied would increase credibility #blueJC
jimgthornton
https://pbs.twimg.com/profile_images/1677440749/EURO_Jim_Thornton_normal.JPG
@elaineleung #bluejc no prob. ask a question?
andreawoolner1
https://pbs.twimg.com/profile_images/378800000589173434/b176b4eb7fe9279c607b380b3ddae96d_normal.jpeg
Hi #blueJC so are findings of other bio markers and their potential predictive value (I also read blog @jimgthornton ) goin to be published?
gynaeresearcher
https://pbs.twimg.com/profile_images/2350090781/matisse_normal.jpg
@jimgthornton #BlueJC to be fair these are the 3 frontrunners. You know these what's measured in StAmP. sFLT1 shown prognostic in animals
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
#blueJC so AUC demonstrating trade-off between sensitivity and specificity..provides a visual demonstration
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
.@JDaru blog by @jimgthornton on different cut-offs were used 4 #preeclampsia in register- not sure how would it change AUC results? #bluejc
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
#blueJC Eg. 60% cases detected with 10% false+’ve rate, or 45% cases detected & 5% false-positive rate
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
#blueJC do you think the difference in AUC between clin+PlGF and clin+USS is clinically significant?
eichelbergerk
https://abs.twimg.com/sticky/default_profile_images/default_profile_5_normal.png
@elaineleung #bluejc A simple read is that it suggests variations of these models are not likely to be more precise. Woodham et al reported
eichelbergerk
https://abs.twimg.com/sticky/default_profile_images/default_profile_5_normal.png
@elaineleung #bluejc a much smaller case control using sFLT, PlGF, + vit D. AUC was 0.85 at best. They looked at severe pre-x only, which
eichelbergerk
https://abs.twimg.com/sticky/default_profile_images/default_profile_5_normal.png
@elaineleung #bluejc theoretically should be easier to detect.
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
Perhaps adding confusion, but use of NICE tool highlight nullips =moderate risk #BlueJC
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
#BlueJC ?inadvertent outcome of the study report is highlighting low sensitivity of NICE tool!
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
What do you think about results in table 4 & 5?- sort of lead to @maireadblack 's questions 2 #BlueJC
martinhirsch100
https://pbs.twimg.com/profile_images/494583242352525312/C2rPaEch_normal.jpeg
Please can people refer to table or page as I have not had long enough reading the paper - apologies. #bluejc
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
#BlueJC Not surprising that compares favourably with NICE tool as downstream variables included..and beyond aspirin opportunity
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
MT @jimgthornton: Probably AUC would be smaller! I suspect if AUC had been bigger with all PE they wld have published that! #bluejc
martinhirsch100
https://pbs.twimg.com/profile_images/494583242352525312/C2rPaEch_normal.jpeg
@elaineleung An NNT of 54 with clin rf and pigf is enough to treat with asprin surely? #bluejc
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
@martinhirsch100 May well be but too late for aspirin by time variables are measured? #BlueJC
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
.@martinhirsch100 being evil- UA doppler has the same post-test probability & already in clinic- shouldn't that be used? #bluejc
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
@martinhirsch100 Good point re. economic? and non-invasive #BlueJC
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
@maireadblack Remind me- what's the evidence of the timing of use 4 aspirin (not my research interest- probably I should have known) #bluejc
anushkatirlapur
https://pbs.twimg.com/profile_images/344513261572773315/5ed0f2fe38092500c1fa3846ea6b0b1e_normal.jpeg
How much is the PIGF test? #bluejc
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
@elaineleung My understanding is best evidence points to use by/before 12/40 #BlueJC
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
RT @maireadblack: @martinhirsch100 I don't know how much this PIGF test gonna cost- but Luminex multiplex analysis isn't cheap. #BlueJC
martinhirsch100
https://pbs.twimg.com/profile_images/494583242352525312/C2rPaEch_normal.jpeg
If they had looked at these markers at the start of the 2nd Trimester it may have provided more useful options to outcomes #bluejc
andreawoolner1
https://pbs.twimg.com/profile_images/378800000589173434/b176b4eb7fe9279c607b380b3ddae96d_normal.jpeg
@elaineleung agree - theres not signif diff in AUC for +Doppler or +pigf; would it be interesting 2see table 5 type for clin+Doppler?#blueJC
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
Does it matter that details of power calculation not provided? Would an estimation of power aid interpretation of the findings?#blueJC
jimgthornton
https://pbs.twimg.com/profile_images/1677440749/EURO_Jim_Thornton_normal.JPG
#Bluejc Does anybody in this JC actually believe that PlGF at 15w really adds anything to clinical risk prediction of PE? I don't.
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
I really like how they presented data as table 5- and agree w/ @AndreaWoolner1: AUC for +Doppler or +pigf #blueJC
andreawoolner1
https://pbs.twimg.com/profile_images/378800000589173434/b176b4eb7fe9279c607b380b3ddae96d_normal.jpeg
@martinhirsch100 but if current advised intervention best in 1st trimester is there point of 2nd trimester screening test? #blueJC
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
#BlueJC Statistician's concern would be high number of variables included in model and low number of events
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
Being an evil advocate- @jimgthornton can you elaborate on why not? #bluejc
andreawoolner1
https://pbs.twimg.com/profile_images/378800000589173434/b176b4eb7fe9279c607b380b3ddae96d_normal.jpeg
@jimgthorton no not based on this paper, particularly as clin+USS appears similar and is readily available / not expensive, etc #blueJC
jimgthornton
https://pbs.twimg.com/profile_images/1677440749/EURO_Jim_Thornton_normal.JPG
@jimgthornton #bluejc if this was RCT with 1ry & 2ry endpoints not reported & modest effect for 3rd new endpoint BJOG wld have rejected.
janecurrie
https://pbs.twimg.com/profile_images/1548110510/image_normal.jpg
Late to the party...just seen the line re 90% Caucasian participants despite multicentre international etc. Surprising! #bluejc
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
.@jimgthornton Even with STROBE and the popularity of registration for cohort studies- there are lots to do on reporting these! #bluejc
andreawoolner1
https://pbs.twimg.com/profile_images/378800000589173434/b176b4eb7fe9279c607b380b3ddae96d_normal.jpeg
I am wondering thoughts on statement pg 1221 on using controls with other complications & relevance for study on screening #blueJC
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
I think the conversation is leading back to @jimgthornton 's point- "where is the main study?" #bluejc
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
RT @jimgthornton: I've not seen a paper showing prediction of predefined endpoints at this gestation #bluejc
janecurrie
https://pbs.twimg.com/profile_images/1548110510/image_normal.jpg
.@elaineleung @martinhirsch100 UA doppler fairly widely available but not universal.Expansion has massive cost/manpower implications #bluejc
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
@AndreaWoolner1 I think what they meant not to exclude controls with other complications rather than actively seeking for them? #BlueJC
martinhirsch100
https://pbs.twimg.com/profile_images/494583242352525312/C2rPaEch_normal.jpeg
I think we are still looking for an accurate predictive marker of PE #bluejc
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
@AndreaWoolner1 Yes I think they are arguing that its a more pragmatic approach #BlueJC
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
But luminex plate is >100 pounds each (plus manpower). MT @janecurrie @martinhirsch100 UA doppler expansion has cost implications #bluejc
eichelbergerk
https://abs.twimg.com/sticky/default_profile_images/default_profile_5_normal.png
@jimgthornton #bluejc To answer your ?, no I don't think so. But I also think that we are unlikely to develop an early screening tool to
martinhirsch100
https://pbs.twimg.com/profile_images/494583242352525312/C2rPaEch_normal.jpeg
@janecurrie UAD are what 15-20% postive predictive value with aspirin as a treatment that is not particularly effective #bluejc
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
RT @jimgthornton: In contrast 2 late PlGF when disease process has started where shennan's recent lancet paper did predefine endpt. #bluejc
gynaeresearcher
https://pbs.twimg.com/profile_images/2350090781/matisse_normal.jpg
@jimgthornton #bluejc diagnostic yield reduced if clinician doesn't believe result http://t.co/G4q9keYgXQ
eichelbergerk
https://abs.twimg.com/sticky/default_profile_images/default_profile_5_normal.png
@jimgthornton #bluejc identify the 19 women in the cohort (0.53%) who developed our true outcome of interest (prex < 34 weeks).
eichelbergerk
https://abs.twimg.com/sticky/default_profile_images/default_profile_5_normal.png
#bluejc I wish David Grimes or Ken Schultz could weight in re: utility of screening tests for rare outcomes, and how to define "rare."
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
It sounds like the more we read into this, the less we are convinced by the results of this #BlueJC paper
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
#BlueJC Useful discussion to highlight what makes a strong prospective cohort study for prediction purposes
martinhirsch100
https://pbs.twimg.com/profile_images/494583242352525312/C2rPaEch_normal.jpeg
Screening & treating vs more midwifery appointments looking at neonatal outcomes would interest me #bluejc
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
Being another evil advocate again-odd that they used luminex analysis (which typically analyse large number of markers in one go…) #bluejc
gynaeresearcher
https://pbs.twimg.com/profile_images/2350090781/matisse_normal.jpg
@AndreaWoolner1 think its ok, represents popln at risk - preg outcome not known at time of screening, selected indep of outcome #bluejc
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
RT @maireadblack: @martinhirsch100 Indeed..particularly health economics involved!#BlueJC
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
#BlueJC Any thoughts on what to anticipate from the total cohort findings?
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
.@jimgthornton @Maireadblack at least there is supposedly the complete data coming out- hopefully soonish! #bluejc
jimgthornton
https://pbs.twimg.com/profile_images/1677440749/EURO_Jim_Thornton_normal.JPG
@elaineleung #bluejc indeed. see Alere response http://t.co/nM7loi6OwL 47 assays [...] were measured by Alere in all 15-week samples,
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
#BlueJC Thoughts on the Pharma-University collaboration?
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
.@jimgthornton I like how they communicated risks & potential clinical implication (table 4 &5). Should learn from them for this! #bluejc
anushkatirlapur
https://pbs.twimg.com/profile_images/344513261572773315/5ed0f2fe38092500c1fa3846ea6b0b1e_normal.jpeg
Pharma collaboration always useful when expensive tests are involved. Individual hospitals/labs may not have the expertise #bluejc
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
.@maireadblack on Pharma-Uni collaboration- certainly has its place. Need lots of guts & prospective negotiations to deal w/ results #bluejc
gynaeresearcher
https://pbs.twimg.com/profile_images/2350090781/matisse_normal.jpg
#bluejc recruitment complete at 5690 so still v few proper preterm PE. Looking fwd to seeing paper tho
jimgthornton
https://pbs.twimg.com/profile_images/1677440749/EURO_Jim_Thornton_normal.JPG
@elaineleung @Profkkhan #bluejc BJOG editors. Is reporting 47 assays 3 at a time salami public? Ditto reporting<34<37&total PE seperately?
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
@jimgthornton mentioned something about SCOPE2 >> any links and data. @GynaeResearcher (googled w/o success) #bluejc
jimgthornton
https://pbs.twimg.com/profile_images/1677440749/EURO_Jim_Thornton_normal.JPG
@elaineleung @GynaeResearcher #bluejc I believe @louiseckenny has plans for SCOPE2.
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
@jimgthornton Something for the capture period to continue this discussion #bluejc. Not sure if @Profkkhan is free at the mo!
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
.@maireadblack need to see which are the markers (can't remember all). but these r actually the more well researched ones…#bluejc
profkkhan
https://pbs.twimg.com/profile_images/3418430054/40f16a0a7caad0ba17e67e0d620f4cf7_normal.jpeg
#bluejc I am available. What is the question.
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
.@Maireadblack I suspect results will provide clues 4 further translational research 2 understand #preeclampsia rather than answers #bluejc
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
RT @jimgthornton: @Profkkhan #bluejc BJOG editors. Is reporting 47 assays 3 at a time salami public? Ditto reporting<34<37&total PE...
jimgthornton
https://pbs.twimg.com/profile_images/1677440749/EURO_Jim_Thornton_normal.JPG
@maireadblack #bluejc. surely total cohort won't add much. all the PE's were included in this paper.
gynaeresearcher
https://pbs.twimg.com/profile_images/2350090781/matisse_normal.jpg
Can anyone explain why they converted PIGF to Multips of Median coz changed bwtn 15 +20wks b4 putting into model? #bluejc
jimgthornton
https://pbs.twimg.com/profile_images/1677440749/EURO_Jim_Thornton_normal.JPG
@Profkkhan is it salami to report biomarkers 3 at a time out of 47. plus report <34, <37 and total PE separately? #bluejc
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
@GynaeResearcher @AndreaWoolner1 @AnushkaTirlapur- @Maireadblack asked- what's your guess on the final results? #bluejc
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
@martinhirsch100 any speculation on the final results? #bluejc
anushkatirlapur
https://pbs.twimg.com/profile_images/344513261572773315/5ed0f2fe38092500c1fa3846ea6b0b1e_normal.jpeg
minimal benefit using markers - invasive and expensive so will not change current practice #bluejc
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
@GynaeResearcher (converted PIGF to Multips of Median) Is that the description at the bottom of table 4? #bluejc
jdaru
https://pbs.twimg.com/profile_images/2874320195/630e8f5717efdf7639550a7fe7a286ae_normal.jpeg
@AnushkaTirlapur very large and well powered trial, resulting in no real tangible clinical benefit #bluejc
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
What should we tell the women in the scenario? (apart from asking why she asked) #bluejc @Maireadblack
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
RT @maireadblack: #blueJC lots covered in one hr..looking forward to capturing more over next 7days ^EL
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
"why they converted PIGF > Multips of Median" RT @jimgthornton: > sensible cos normal values change w/ GA. Same in Down screening #bluejc
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
@GynaeResearcher Perhaps need more help with explaining converting PIGF> multis of median! #bluejc (resources would be great!)
profkkhan
https://pbs.twimg.com/profile_images/3418430054/40f16a0a7caad0ba17e67e0d620f4cf7_normal.jpeg
@jimgthornton apart from concerns over salami I would question analyses that do not consider interrelationships between tests #bluejc
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
Thanks! @Maireadblack for the interesting #bluejc- will have a look into the modelling methods later in the next 7 days! @GynaeResearcher
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
RT @Profkkhan: apart from concerns over salami I would question analyses that do not consider interrelationships between tests #bluejc
jimgthornton
https://pbs.twimg.com/profile_images/1677440749/EURO_Jim_Thornton_normal.JPG
@Profkkhan i guess that means report all 47 in same paper. #bluejc
profkkhan
https://pbs.twimg.com/profile_images/3418430054/40f16a0a7caad0ba17e67e0d620f4cf7_normal.jpeg
analysis shows that papers discussed in #bluejc are downloaded more often. Keep the exchange going for better science dissemination
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
RT @Profkkhan: analysis shows> papers discussed in #bluejc r downloaded more often. Keep the exchange going 4 better science dissemination
amcunningham
https://pbs.twimg.com/profile_images/485372180675301376/WVnUe6Wj_normal.jpeg
RT @elaineleung: RT @Profkkhan: analysis shows> papers discussed in #bluejc r downloaded more often. Keep the exchange going 4 better scien…
bwmol
https://pbs.twimg.com/profile_images/459932088557268992/df7m20Af_normal.jpeg
RT @Profkkhan: analysis shows that papers discussed in #bluejc are downloaded more often. Keep the exchange going for better science dissem…
drfloodster
https://pbs.twimg.com/profile_images/378800000498728674/60cbf2ca5a316ee179a3cec1fb75c21c_normal.jpeg
Does any test stand above the clinical risk analysis of the booking patient? With the UAD PPV at 20% and no marker here, what next? #bluejc
drfloodster
https://pbs.twimg.com/profile_images/378800000498728674/60cbf2ca5a316ee179a3cec1fb75c21c_normal.jpeg
@jimgthornton will the salami allow dramatic build up to a big result? Or just more papers per study? #bluejc
hrmorriss
https://pbs.twimg.com/profile_images/378800000100601857/39c33706f5ef8904ce30e5daddc1bc91_normal.jpeg
@drfloodster plgf marginally improves the performance of clinical risk models in first pregnancy as they have no prev obs hx to help #blueJC
drfloodster
https://pbs.twimg.com/profile_images/378800000498728674/60cbf2ca5a316ee179a3cec1fb75c21c_normal.jpeg
@hrmorriss thankfully there's more than just obs hx to use but thanks for the info. Hope we get usable tests soon from thse studies #bluejc
hrmorriss
https://pbs.twimg.com/profile_images/378800000100601857/39c33706f5ef8904ce30e5daddc1bc91_normal.jpeg
@drfloodster other clinical risk factors nowhere near as predictive as obs history as per #NICE #BlueJC
hrmorriss
https://pbs.twimg.com/profile_images/378800000100601857/39c33706f5ef8904ce30e5daddc1bc91_normal.jpeg
@maireadblack for power calculation think they used estimation of accuracy see methods #bluejc
jimgthornton
https://pbs.twimg.com/profile_images/1677440749/EURO_Jim_Thornton_normal.JPG
@hrmorriss @drfloodster IMHO No way! Reasons 1. overfitting, 2. post hoc selection of tests. 3. post hoc seln. of endpoints #bluejc
jimgthornton
https://pbs.twimg.com/profile_images/1677440749/EURO_Jim_Thornton_normal.JPG
@hrmorriss @maireadblack Power calc meaningless if u don't stick to analysis plan #bluejc
dsiassakos
https://pbs.twimg.com/profile_images/378800000670502198/48a5a10a056f10f3ab364497e497e82e_normal.jpeg
RT @EichelbergerK: @elaineleung @maireadbloack @jimgthornton #bluejc Curious if these 3 biomarkers were selected a priori for this analysis?
dsiassakos
https://pbs.twimg.com/profile_images/378800000670502198/48a5a10a056f10f3ab364497e497e82e_normal.jpeg
RT @jimgthornton: #bluejc If u've not read blog. I'm critical of authors for changing 1ry endpoint from all PE to PE<37 weeks betwn registr…
dsiassakos
https://pbs.twimg.com/profile_images/378800000670502198/48a5a10a056f10f3ab364497e497e82e_normal.jpeg
@AnushkaTirlapur : need full proper economic evaluation #bluejc
dsiassakos
https://pbs.twimg.com/profile_images/378800000670502198/48a5a10a056f10f3ab364497e497e82e_normal.jpeg
RT @AndreaWoolner1: @elaineleung agree - theres not signif diff in AUC for +Doppler or +pigf; would it be interesting 2see table 5 type for
dsiassakos
https://pbs.twimg.com/profile_images/378800000670502198/48a5a10a056f10f3ab364497e497e82e_normal.jpeg
RT @maireadblack: Does it matter that details of power calculation not provided? Would an estimation of power aid interpretation of the fin
dsiassakos
https://pbs.twimg.com/profile_images/378800000670502198/48a5a10a056f10f3ab364497e497e82e_normal.jpeg
@AndreaWoolner1 @martinhirsch100 critical point #bluejc
dsiassakos
https://pbs.twimg.com/profile_images/378800000670502198/48a5a10a056f10f3ab364497e497e82e_normal.jpeg
@maireadblack rule of thumb for each variable included in the model 10-20 events needed #bluejc
dsiassakos
https://pbs.twimg.com/profile_images/378800000670502198/48a5a10a056f10f3ab364497e497e82e_normal.jpeg
RT @elaineleung: .@maireadblack on Pharma-Uni collaboration- certainly has its place. Need lots of guts & prospective negotiations to deal
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
@jimgthornton @elaineleung Sorry still unable to identify lancet paper mentioned! #bluejc
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
RT @jimgthornton: I'm sorry. I saw a prepublication draft. it's not published yet. My mistake. 1st author Lucy Chappell #BlueJC
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
RT @jimgthornton: @DSiassakos @JDaru No, that was for prediction of PT birth. The PE primary was "all PE from rand to 2w post del". #BlueJC
gineblog
https://pbs.twimg.com/profile_images/2711872512/18892054712cc6f96fcf898eff9462f5_normal.jpeg
RT @BJOGTweets: Next #BlueJC Monday 14th Oct 18.30 BST Predicting preterm preeclampsia:  http://t.co/OoqrMX6bDQ Discussion points: http://t…
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
@gineblog You can still leave comments abt the paper: #BlueJC Predicting preterm preeclampsia:  http://t.co/iW8NBCaLq4
thedigidoc
https://pbs.twimg.com/profile_images/2789816035/35cbf6ff543980ddbbf7408756279e62_normal.jpeg
@MattBultitude We are looking forward to it too. Might be interesting to connect with @elaineleung of #BlueJC
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
Discussing with @DSiassakos about #bluejc 's paper
sherif_fattah
https://pbs.twimg.com/profile_images/378800000520783160/d61cfa00ec80246c0f83a5b79a83c860_normal.jpeg
#bluejc
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
A little snapshot of stats of #bluejc on Monday. Still lots to do! http://t.co/72lOfXKPyl
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
@MattBultitude- this is the BJOG Journal Club page w/ complementary info (since May 13; piloted from Sept 12) http://t.co/3TyEMXcNas #bluejc
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
RT @elaineleung: A little snapshot of stats of #bluejc on Monday. Still lots to do! http://t.co/72lOfXKPyl
dsiassakos
https://pbs.twimg.com/profile_images/378800000670502198/48a5a10a056f10f3ab364497e497e82e_normal.jpeg
RT @Profkkhan: analysis shows that papers discussed in #bluejc are downloaded more often. Keep the exchange going for better science dissem…
dsiassakos
https://pbs.twimg.com/profile_images/378800000670502198/48a5a10a056f10f3ab364497e497e82e_normal.jpeg
RT @elaineleung: A little snapshot of stats of #bluejc on Monday. Still lots to do! http://t.co/72lOfXKPyl
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
Thanks! A nice summary of the value of Twitter for doctors. http://t.co/IKPG0nEtJs v @alcoss- reminds me of the discussion abt #BlueJC
profkkhan
https://pbs.twimg.com/profile_images/3418430054/40f16a0a7caad0ba17e67e0d620f4cf7_normal.jpeg
RT @elaineleung: A little snapshot of stats of #bluejc on Monday. Still lots to do! http://t.co/72lOfXKPyl
dsiassakos
https://pbs.twimg.com/profile_images/378800000670502198/48a5a10a056f10f3ab364497e497e82e_normal.jpeg
RT @elaineleung: Thanks! A nice summary of the value of Twitter for doctors. http://t.co/IKPG0nEtJs v @alcoss- reminds me of the discussion
dsiassakos
https://pbs.twimg.com/profile_images/378800000670502198/48a5a10a056f10f3ab364497e497e82e_normal.jpeg
RT @elaineleung: @gineblog You can still leave comments abt the paper: #BlueJC Predicting preterm preeclampsia:  http://t.co/iW8NBCaLq4
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
The end of the capture period of the last #BlueJC is TOMORROW. Leave your comments about Myers et al. http://t.co/PffjiRUwqI
profkkhan
https://pbs.twimg.com/profile_images/3418430054/40f16a0a7caad0ba17e67e0d620f4cf7_normal.jpeg
#bluejc creates a scientific buzz online http://t.co/EPS9Tcnx1y
profkkhan
https://pbs.twimg.com/profile_images/3418430054/40f16a0a7caad0ba17e67e0d620f4cf7_normal.jpeg
RT @LitRoost: #BlueJC: BJOG and Katherine Twining Network increase post-pub peer review and research literacy via a Twitter club http://t.…
profkkhan
https://pbs.twimg.com/profile_images/3418430054/40f16a0a7caad0ba17e67e0d620f4cf7_normal.jpeg
RT @bejiuli: #ACOGChat http://t.co/ughrBSGxQI risks of Medicines pharmaceuticalColumbia healthcare protection #bluejc
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
#BlueJC discussed;research Q, choice of outcomes, RFs, power calc, stats, interpretation, pharma-uni, value, £implications, salami &more
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
#BlueJC Any further comments on this paper – take your chance in the next 24hrs! http://t.co/4sSVNng8hf
maireadblack
https://pbs.twimg.com/profile_images/378800000706529749/26b598c556fa8de3796b9f9eb5ea7c01_normal.jpeg
#BlueJC My response to woman in scenario; Reassure (not at high risk) Explain (no useful test yet) Plan (routine care usually IDs PET early)
drfloodster
https://pbs.twimg.com/profile_images/378800000498728674/60cbf2ca5a316ee179a3cec1fb75c21c_normal.jpeg
#bluejc on recent experience I await the breakthrough from this research to aim prediction inc race specific info. African pop unpredictable
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
RT @LitRoost: #BlueJC: BJOG and Katherine Twining Network increase post-pub peer review and research literacy via a Twitter club http://t.…
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
RT @maireadblack: #BlueJC Any further comments on this paper – take your chance in the next 24hrs! http://t.co/4sSVNng8hf
elaineleung
https://pbs.twimg.com/profile_images/378800000817164734/16e8deb5ce64517e83a57fb64c3a58f1_normal.jpeg
RT @drfloodster: #bluejc on recent experience I await the breakthrough from this research to aim prediction inc race specific info. African…
sadiabhatti2
https://abs.twimg.com/sticky/default_profile_images/default_profile_6_normal.png
#BlueJC - News - BJOG: An International Journal of Obstetrics & Gynaecology http://t.co/C48w42juNw

Content from Twitter