#ecuimres transcript

Healthcare Social Media Transcript

From: Tue Jan 15 9:00:00 PST 2013
To: Tue Jan 15 11:45:00 PST 2013

What is #ecuimres? Who were the influencers during this time period? #ecuimres analytics


Healthcare Conference  - Healthcare Tweet Chats  -  Healthcare Analytics

nephondemand
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#ecuimres #renal #journalclub 1/15 #tuberous sclerosis: by Dr W Ahmed; starts in 5 minutes; tweets coming live
nephondemand
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#ecuimres #renal #journalclub 1/15 #tuberous sclerosis: starts with a case of 57 M w/TS & CKD x 5 yrs; Cr 1.7 in 2007 --> 4.2 in 2012
nephondemand
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#ecuimres #renal #journalclub 1/15 #tuberous sclerosis: trend in Cr shown here http://t.co/ZTvdUp1H
nephondemand
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#ecuimres #renal #journalclub 1/15 #tuberous sclerosis: CT coronal sections show cysts & #angiomyolipas http://t.co/OME0dnAv
nephondemand
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#ecuimres #journalclub #tuberous sclerosis: Cr rising so we asked the expert in TS: Dr Bissler: 90% have CKD-1 b/o cyst or tumor compression
nephondemand
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#ecuimres #renal #journalclub 1/15 #tuberous sclerosis: ?: what can we do to lower cyst burden, & therefore lower risk of CKD progression?
nj2821
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#ecuimres 90 percent get angiomyolipomata and 60 percent get cysts____ tuberous sclerosis
nephondemand
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#ecuimres #renal #journalclub 1/15 #tuberous sclerosis: TSC 1st described in 1880; initially called #Bourneville-Pringle disease
nephondemand
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#ecuimres #renal #journalclub #tuberous sclerosis: is an #autosomal dominant multi-organ disease; but 70-80% of pts have no known family hx
nephondemand
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#ecuimres #renal #journalclub #tuberous sclerosis:mutations r in TSC 1 hamartin (ch 9q) or TSC 2 tuberlin (ch 16p); both r tumor suppressors
nephondemand
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#ecuimres #journalclub #tuberous sclerosis: RCC develops in 2-3% of pts (in 3rd decade) who have #renal involvement (55-75% of all TS pts)
nephondemand
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#ecuimres #renal #journalclub 1/15 #tuberous sclerosis: #nephrolithiasis greater b/o cysts & use of #topiramate 2 stop seizures
nephondemand
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#ecuimres #renal #journalclub 1/15 #tuberous sclerosis: #topiramate blocks #citrate excretion, causing higher risk of #calcareous stones
nephondemand
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#ecuimres #renal #journalclub 1/15 #tuberous sclerosis: #angiomyolipomas have tendency 2 bleed, which can cause #hypovolemic shock
nephondemand
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#ecuimres #journalclub 1/15 #tuberous sclerosis: perform yearly #cancer surveillance; #renal US q1-3 yrs & MRI if anything is abnormal
nephondemand
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#ecuimres #renal #journalclub 1/15 #tuberous sclerosis: #mTOR is in the pathway for developing cysts
nephondemand
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#ecuimres #renal #journalclub 1/15 #tuberous sclerosis: NEJM article 2 assess #sirolimus effect @ reducing #angiomyolipoma volume
nephondemand
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#ecuimres #journalclub #tuberous sclerosis: #sirolimus @ 0.25 mg/m2 for levels 1-5 Ng/ml; dose increased if volume size decreased < 10%
nephondemand
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#ecuimres #renal 1/15 #tuberous sclerosis: w/ #sirolimus #angiomyolipomas decreased in volume & increased w/drug d/c http://t.co/9uBiP12v
nephondemand
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#ecuimres #renal #journalclub 1/15 #tuberous sclerosis: mean volume at 12 months was 53+-27% reduction from baseline (p < 0.001)
nephondemand
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#ecuimres #renal #journalclub 1/15 #tuberous sclerosis: mean volume at 24 months was 86+-27% reduction from ... http://t.co/banXO8SX
nephondemand
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#ecuimres #renal #journalclub 1/15 #tuberous sclerosis: NDT 2010: case report of using #sirolimus to decrease #angiomyolipoma size
nephondemand
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#ecuimres #renal #journalclub 1/15 #tuberous sclerosis: take home points: use #sirolimus to decrease #angiomyolipoma volume
nephondemand
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#ecuimres #renal #journalclub 1/15 #tuberous sclerosis: take home points: should c maximum effect in 1st yr, but need lifelong therapy
nephondemand
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#ecuimres #renal #journalclub 1/15 #tuberous sclerosis: take home points: decreased #angiomyolipoma size decreases risk for fatal bleeding
nephondemand
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#ecuimres #renal #journalclub 1/15 #tuberous sclerosis: take home points: decreasing #angiomyolipoma volume can halt progression of CKD

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