#NephJC transcript

Healthcare Social Media Transcript

From: Tue Feb 17 17:00:00 PST 2015
To: Wed Feb 18 17:00:00 PST 2015

What is #NephJC? Who were the influencers during this time period? #NephJC analytics


Healthcare Conference  - Healthcare Tweet Chats  -  Healthcare Analytics

hswapnil
https://pbs.twimg.com/profile_images/730502747754139649/hP6Q9DDQ_normal.jpg
RT @NephJC: T-90 minutes to #nephjc 20 #AKI breakthrough? Check out http://t.co/n68IQj25w5 and http://t.co/tuXVnxoHja for talking points
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
T-40 minutes until #NephJC Diagnosis of AKI: new tool, NephroCheck Does it work? What do you do with it?
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
RT @kidney_boy: T-40 minutes until #NephJC Diagnosis of AKI: new tool, NephroCheck Does it work? What do you do with it? #nephjc
azrabihorac
https://pbs.twimg.com/profile_images/530502120009502720/WH1UnphS_normal.jpeg
#nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
test tweet - ruling out tchat.io bugs #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
RT @kidney_boy: T-40 minutes until #NephJC Diagnosis of AKI: new tool, NephroCheck Does it work? What do you do with it?
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
If you are going to join tonight’s #NephJC take a look at the topics. This is something new we are trying. http://t.co/EqSt42x75V
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
AKI staging redux from @goKDIGO for tonight's #Nephjc http://t.co/zd4zAIhqX4
hswapnil
https://pbs.twimg.com/profile_images/730502747754139649/hP6Q9DDQ_normal.jpg
RT @kidney_boy: If you are going to join tonight’s #NephJC take a look at the topics. This is something new we are trying. http://t.co/EqSt42x75V
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
RT @kidney_boy: #NephJC take a look at the topics. Great idea This is something new we are trying. http://t.co/3eAeToYuBo #nephjc
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
My former resident and now AKI big shot @jaykoyner joined Twitter. I suspect he will be joining tonight’s #NephJC
azrabihorac
https://pbs.twimg.com/profile_images/530502120009502720/WH1UnphS_normal.jpeg
#nephjc @kidney_boy great choice of questions
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
@NephJC tchat.io seems slow and some errors on RTs #nephjc
hswapnil
https://pbs.twimg.com/profile_images/730502747754139649/hP6Q9DDQ_normal.jpg
@kidney_boy @AzraBihorac BTW @kellumja is also on Twitter - but he said he's busy #Nephjc
hswapnil
https://pbs.twimg.com/profile_images/730502747754139649/hP6Q9DDQ_normal.jpg
@kidney_boy: Look who will be joining “@AzraBihorac: #nephjc looking forward to participate tonight” http://t.co/pp6ji7htEJ”
gabolino43
https://pbs.twimg.com/profile_images/478854920649457664/0CRrMmV9_normal.jpeg
RT @NephJC: AKI staging redux from @goKDIGO for tonight's #Nephjc http://t.co/zd4zAIhqX4
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
@hswapnil @kidney_boy thanks for fixing that hashtag #NephJC
pednephrol
https://pbs.twimg.com/profile_images/1744924654/RETRATO_MST_2012_JAN_normal.jpg
RT @NephJC: AKI staging redux from @goKDIGO for tonight's #Nephjc http://t.co/zd4zAIhqX4
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
@NephJC @goKDIGO those stages give me a headache to look at #NephJC
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
I teach them every month and they are like second nature. Better know the AKI stage when rounding with Dr. Topf. #nephjc
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
@kidney_boy what do you do with them? make residents feel bad? or are they useful? #nephjc
azrabihorac
https://pbs.twimg.com/profile_images/530502120009502720/WH1UnphS_normal.jpeg
@Nephro_Sparks @NephJC @goKDIGO #nephjc AKI stages are simple and intuitive if you just let them grow with you
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
@kidney_boy asking for a friend #nephjc
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
Make them feel bad. This is nephrology. Am I doing it wrong? #nephjc
hswapnil
https://pbs.twimg.com/profile_images/730502747754139649/hP6Q9DDQ_normal.jpg
@kidney_boy so do I. But am not sure of clinical utility #NephJC
jaykoyner
https://pbs.twimg.com/profile_images/651800506654945280/T_jfv8F__normal.jpg
at the bedside they are useful but their real strength is in research - comparing across cohorts - like an apache or sofa score #nephjc
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
I think for docs with a lot of AKI experience glean the prognosis of any particular AKI subconsciously, but... #nephjc
azrabihorac
https://pbs.twimg.com/profile_images/530502120009502720/WH1UnphS_normal.jpeg
@hswapnil @kidney_boy #nephjc incredibly important. Simplest example is adjusting all your drugs for drop in GFR that corresponds to them
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
for others with less experience the stage can give them a feel for severity. #nephjc
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
@kidney_boy anuric with creat going from 1-->10 = severe #nephjc
azrabihorac
https://pbs.twimg.com/profile_images/530502120009502720/WH1UnphS_normal.jpeg
@kidney_boy #nephjc for any good intensifier they should become your second nature
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
@AzraBihorac @hswapnil I usually assume GFR is zero until the cr stabilizes. #nephjc
azrabihorac
https://pbs.twimg.com/profile_images/530502120009502720/WH1UnphS_normal.jpeg
@kidney_boy @hswapnil #nephjc in ICU it is quite important for non nephrologist
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
+1 RT @AzraBihorac: @kidney_boy @hswapnil #nephjc in ICU it is quite important for non nephrologist
brownpa79
https://pbs.twimg.com/profile_images/668887816454152192/WSSSjK2O_normal.jpg
+1 RT @Nephro_Sparks: @NephJC @goKDIGO those stages give me a headache to look at #NephJC
langoteamit
https://pbs.twimg.com/profile_images/618996490665488384/RYS5ZWFm_normal.jpg
RT @Nephro_Sparks: @NephJC @goKDIGO those stages give me a headache to look at #NephJC
azrabihorac
https://pbs.twimg.com/profile_images/530502120009502720/WH1UnphS_normal.jpeg
#nephjc for good intensivist your AKI patient NOT progressing to RRT is equal saving his life before and after discharge
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
RT @AzraBihorac: #nephjc for good intensivist your AKI patient NOT progressing to RRT is equal saving his life before and after discharge
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
Best part of Faubel's intro was the picture of the Space Shuttle to represent the Discovery Study! #NephJC http://t.co/nLMl0iWDlt
texaskiddoc
https://pbs.twimg.com/profile_images/626166016037548032/rXCAPqpM_normal.jpg
Yes! (My babies either pee fine or nothing) @kidney_boy: @AzraBihorac @hswapnil I usually assume GFR is zero until the cr stabilizes #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
Welcome to #nephjc 20! This is the first time we tackle true #AKI (not that pretender - contrast AKI) Details at http://t.co/n68IQiKuEx
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
The summary for this #nephjc was written by @doc_faubel from UC Denver http://t.co/HauLufRsig
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
Joel is busy with #Nephmadness so the keys of #Nephjc tonight are back with Swapnil @hswapnil http://t.co/7sFDJ4lLfn
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
Matt Sparks, Durham, NC, (wanting to put end to all AKI) no COI (deep in #NephMadness land) #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
A first today is that we will have talking points T0/1-2-3 - details to follow (if U missed the #nephJC mailing!) So preface ur tweet T/n
ctsinclair
https://pbs.twimg.com/profile_images/799086391221067777/9trLk4H3_normal.jpg
RT @kidney_boy: I teach them every month and they are like second nature. Better know the AKI stage when rounding with Dr. Topf. #nephjc
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
Joel Topf, co creator of #NephJC. co creator of #NephMadness. Serious Coffee Addict. #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
#NephJC recommends using a client like tchat.io or http://t.co/rFoH4MVMzu to enter the virtual chatroom and get the full experience
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
So now please introduce yourself to #NephJC and declare any conflicts of interest (CoI) real or perceived
hswapnil
https://pbs.twimg.com/profile_images/730502747754139649/hP6Q9DDQ_normal.jpg
Swapnil Hiremath, nephrologist @OttawaHospital @uOttawaMed no CoI #nephJC http://t.co/yjN325NUjb
ctsinclair
https://pbs.twimg.com/profile_images/799086391221067777/9trLk4H3_normal.jpg
RT @NephJC: Welcome to #nephjc 20! This is the first time we tackle true #AKI (not that pretender - contrast AKI) Details at http://t.co/n68IQiKuEx
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
If you are lurking and just reading - still introduce yourself once - helps us to gauge #NephJC impact http://t.co/iJVbVkcSHz
brownpa79
https://pbs.twimg.com/profile_images/668887816454152192/WSSSjK2O_normal.jpg
Pierre Antoine Brown, Ottawa, ON. Disclosure @hswapnil office is next to mine #nephjc
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
Nice to see Emily @TexasKidDoc, hope she helps with the rest of the discussion #nephjc
langoteamit
https://pbs.twimg.com/profile_images/618996490665488384/RYS5ZWFm_normal.jpg
Amit Langote , Nephrology Fellow , Ottawa, Really curious abt this biomarker, No COI #nephjc
teerath1978
https://pbs.twimg.com/profile_images/669012113181048832/utq6N9kB_normal.jpg
Teerath kumar, Nephrolgy fellow, ottawa #nephjc
azrabihorac
https://pbs.twimg.com/profile_images/530502120009502720/WH1UnphS_normal.jpeg
@NephJC #nephjc Azra Bihorac participated in Saphire and Topaz as researcher
dr_nikhilshah
https://pbs.twimg.com/profile_images/801651738524598272/d9uOVZ_9_normal.jpg
Nikhil Shah - Nephrology Fellow, Univ of Alberta, Edmonton. #nephjc
langoteamit
https://pbs.twimg.com/profile_images/618996490665488384/RYS5ZWFm_normal.jpg
RT @brownpa79: Pierre Antoine Brown, Ottawa, ON. Disclosure @hswapnil office is next to mine #nephjc
hecmagsmd
https://pbs.twimg.com/profile_images/555936314122842113/5A3PrkXC_normal.jpeg
Hector Madariaga, SUNY Upstate. Nephrology fellow and NSMC intern. #nephjc
doc_faubel
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sarah faubel , university of colorado Denver. no COI. I worked hard on finding pictures for the intro! #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
Ho Joel, Matt, Pierre, Nikhil, Hector and Teerath - and great to have an author in the house Azra! #nephjc
kidney_md
https://pbs.twimg.com/profile_images/2773691458/7bef40f1562a551baf2894a1a08c5cff_normal.jpeg
Paras Dedhia, Neph fellow, Univ of CIncinnati. No COI #NephJC
hecmagsmd
https://pbs.twimg.com/profile_images/555936314122842113/5A3PrkXC_normal.jpeg
@kidney_boy @hswapnil @Nephro_Sparks You all had an early start today! :) #NephJC
langoteamit
https://pbs.twimg.com/profile_images/618996490665488384/RYS5ZWFm_normal.jpg
RT @doc_faubel: sarah faubel , university of colorado Denver. no COI. I worked hard on finding pictures for the intro! #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
Thanks for joining Sarah - great intro! #nephjc
dr_nikhilshah
https://pbs.twimg.com/profile_images/801651738524598272/d9uOVZ_9_normal.jpg
RT @NephJC: Ho Joel, Matt, Pierre, Nikhil, Hector and Teerath - and great to have an author in the house Azra! #nephjc
jaykoyner
https://pbs.twimg.com/profile_images/651800506654945280/T_jfv8F__normal.jpg
Jay Koyner -capricorn, biomarker investigator , twitter padawan and participant in both the sapphire and Topaz studies - #nephjc
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
The NSMC Fellows are out in force tonight. Ho Hektor, Ho Nikhil #nephjc
dr_nikhilshah
https://pbs.twimg.com/profile_images/801651738524598272/d9uOVZ_9_normal.jpg
RT @kidney_boy: The NSMC Fellows are out in force tonight. Ho Hektor, Ho Nikhil #nephjc
hecmagsmd
https://pbs.twimg.com/profile_images/555936314122842113/5A3PrkXC_normal.jpeg
RT @kidney_boy: The NSMC Fellows are out in force tonight. Ho Hektor, Ho Nikhil #nephjc
nephjc
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Welcome back Paras! And Joel warned us you are coming Jay! #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
RT @kidney_boy: The NSMC Fellows are out in force tonight. Ho Hektor, Ho Nikhil #nephjc
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
@HekmagsMD what up Hector!! #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
This is just the first part of #NephJC for the Americas. The EU/African GMT chat is fast growing in popularity
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
Welcome Jay. What's Capricom? @jaykoyner #nephjc
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
@dr_nikhilshah the famous Nikhil (screwdriver story) Shah #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
& hit that follow button - a puppy dies after any #NephJC that U don't follow some1 new. JK - it's actually a kitten http://t.co/fux7wf3dOQ
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
RT @Nephro_Sparks: @dr_nikhilshah the famous Nikhil (screwdriver story) Shah #nephjc
dr_nikhilshah
https://pbs.twimg.com/profile_images/801651738524598272/d9uOVZ_9_normal.jpg
LOL! RT @Nephro_Sparks: @dr_nikhilshah the famous Nikhil (screwdriver story) Shah #nephjc
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
@doc_faubel Welcome, thanks for doing an awesome write up. Great work. Great Visuals. #nephjc
hecmagsmd
https://pbs.twimg.com/profile_images/555936314122842113/5A3PrkXC_normal.jpeg
@Nephro_Sparks @HekmagsMD Professor Sparks! Freezing up here and buried in snow. How about you!? #nephjc
langoteamit
https://pbs.twimg.com/profile_images/618996490665488384/RYS5ZWFm_normal.jpg
RT @Nephro_Sparks: @dr_nikhilshah the famous Nikhil (screwdriver story) Shah #nephjc
dr_nikhilshah
https://pbs.twimg.com/profile_images/801651738524598272/d9uOVZ_9_normal.jpg
@Nephro_Sparks @dr_nikhilshah Actually started my first experience with SLEDD!! #nephjc
kidney_md
https://pbs.twimg.com/profile_images/2773691458/7bef40f1562a551baf2894a1a08c5cff_normal.jpeg
RT @Nephro_Sparks: @dr_nikhilshah the famous Nikhil (screwdriver story) Shah #nephjc
abigotincidence
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Mark Anthony Tom, Philippines. No COI. Priming my machines and tweeting. #NephJC
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
@dr_nikhilshah a SLED for ice or the ICU? #nephjc
jaykoyner
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@kidney_boy - should have been capricorn thanks for calling out my typo #nephjc
nephjc
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@tomas_md Welcome back, Tom. What time is it there? #nephjc
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
@HekmagsMD we had 0.8 inches of ice and everything was cancelled #nephjc
edgarvlermamd
https://pbs.twimg.com/profile_images/2297302029/image_normal.jpg
Edgar Lerma, Chicago-based Nephrologist #NephJC
dr_nikhilshah
https://pbs.twimg.com/profile_images/801651738524598272/d9uOVZ_9_normal.jpg
ICU SLEDD! I know I am in Edmonton, dont rub it in!! LOL RT @Nephro_Sparks: @dr_nikhilshah a SLED for ice or the ICU? #nephjc
nephjc
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@edgarvlermamd glad you could make it Edgar - looking forward to some #nephpearls #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
T0: How are you currently diagnosing AKI? - μscopy/FENa - @goKDIGO staging - urine output - others? #nephjc http://t.co/ObSgDi6H0c
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
Ho edgar. I'm all critical care bracket after 10 pm. #nephjc
nephjc
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T0: some discussion already started pre-chat - so scroll down and see @Nephro_Sparks nihilism on AKI staging shared by many! #nephjc
hecmagsmd
https://pbs.twimg.com/profile_images/555936314122842113/5A3PrkXC_normal.jpeg
Boring... RT @Nephro_Sparks: @HekmagsMD we had 0.8 inches of ice and everything was cancelled #nephjc
wittykidney
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Malvinder Parmar, Ontaio, no COI #nephjc #nephjc
langoteamit
https://pbs.twimg.com/profile_images/618996490665488384/RYS5ZWFm_normal.jpg
T0 =Oligoanuria , rising creat , Urine microscopy #nephjc
dr_nikhilshah
https://pbs.twimg.com/profile_images/801651738524598272/d9uOVZ_9_normal.jpg
Edmonton a few inches of snow BID! is norm RT @Nephro_Sparks: @HekmagsMD we had 0.8 inches of ice and everything was cancelled #nephjc
nephjc
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@wittykidney nice to see you back Mal! #nephjc
hecmagsmd
https://pbs.twimg.com/profile_images/555936314122842113/5A3PrkXC_normal.jpeg
AKI stages not helpful in clinical setting. I don't think they change management. #nephjc
langoteamit
https://pbs.twimg.com/profile_images/618996490665488384/RYS5ZWFm_normal.jpg
T0= Dont use staging #nephjc
brownpa79
https://pbs.twimg.com/profile_images/668887816454152192/WSSSjK2O_normal.jpg
T0 clinical parameters mostly (U\O, creat, FeNa, ect), very rarely look at AKi stages. #nephjc
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
T0 clinical context is very important as well #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
T0: this is what @goKDIGO suggests we do with staging. Do we agree with this? #nephjc http://t.co/cDA0VbmrVD
doc_faubel
https://pbs.twimg.com/profile_images/534413974788243456/Dnfeg_tE_normal.jpeg
T0= yes creatinine, no to urine output #nephjc
kidney_boy
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One of my favorite things to do in consult nephrology is find dirty brown casts. #NephJC
edgarvlermamd
https://pbs.twimg.com/profile_images/2297302029/image_normal.jpg
@goKDIGO Initial diagnosis (detection) and staging of AKI in adults #Nephpearls #NephJC http://t.co/5CkyTGaPse
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
@doc_faubel Why no to urine output? #nephjc
azrabihorac
https://pbs.twimg.com/profile_images/530502120009502720/WH1UnphS_normal.jpeg
#nephjc Kdigo for staging, renal US and Doppler plus urine protein, microscopy and electrolytes plus mmunological tests when indicated
doc_faubel
https://pbs.twimg.com/profile_images/534413974788243456/Dnfeg_tE_normal.jpeg
T0=staging good to remind everyone that mortality goes up with increased stage of AKI #nephjc
jaykoyner
https://pbs.twimg.com/profile_images/651800506654945280/T_jfv8F__normal.jpg
staging is imperfect - use creatinine and UOP - staging will get better once we have several clinical biomarkers to pair it with #nephjc
langoteamit
https://pbs.twimg.com/profile_images/618996490665488384/RYS5ZWFm_normal.jpg
T0 - i tend to do all of that irrespective of stage. DO we know when AKi stg1 will become stg 2? #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
RT @jaykoyner: staging is imperfect - use creatinine and UOP - staging will get better once we have several clinical biomarkers to pair it with #nephjc
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
@AzraBihorac what immunological tests are you doing? Looking for GNs? #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
RT @doc_faubel: T0=staging good to remind everyone that mortality goes up with increased stage of AKI #nephjc
brownpa79
https://pbs.twimg.com/profile_images/668887816454152192/WSSSjK2O_normal.jpg
T0 - agree with @goKDIGO but we rarely get them in time! consults often come at stage 2-3 #nephjc
wittykidney
https://pbs.twimg.com/profile_images/553936695637606401/GNV7JM5x_normal.jpeg
@AzraBihorac Do we need renal ultrasound and Doppler?...... #nephjc
kidney_md
https://pbs.twimg.com/profile_images/2773691458/7bef40f1562a551baf2894a1a08c5cff_normal.jpeg
RT @brownpa79: T0 - agree with @goKDIGO but we rarely get them in time! consults often come at stage 2-3 #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
@doc_faubel So Prognostic utility - but what is clinical therapeutic use? #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
RT @brownpa79: T0 - agree with @goKDIGO but we rarely get them in time! consults often come at stage 2-3 #nephjc
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
T0- sometimes a gut feeling that creat is getting ready to skyrocket (clinical context of AKI) #nephjc
azrabihorac
https://pbs.twimg.com/profile_images/530502120009502720/WH1UnphS_normal.jpeg
@brownpa79 @goKDIGO #nephjc I works as intensivist I see EVERYBODY at the beginning. Usually if the context is right I do look for GN
abigotincidence
https://pbs.twimg.com/profile_images/815509230983618560/IymFvEIm_normal.jpg
@NephJC @goKDIGO but serum creatinine and urine output very important in diagnosis of AKI. we usually get the referrals late. #NephJC
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
RT @AzraBihorac: #nephjc Kdigo for staging, renal US and Doppler plus urine protein, microscopy and electrolytes plus mmunological tests when indicated
edgarvlermamd
https://pbs.twimg.com/profile_images/2297302029/image_normal.jpg
The Kidney Injury continuum #Nephpearls #NephJC http://t.co/7fPkoLIcat http://t.co/nfOwz81kxH
dr_nikhilshah
https://pbs.twimg.com/profile_images/801651738524598272/d9uOVZ_9_normal.jpg
T0 - Stages are for non nephrologists! They are a marker to get the nephro involved before everything goes south! #nephjc
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
as a consultant we are skewed. When I round on gen med things are more insidious #nephjc
doc_faubel
https://pbs.twimg.com/profile_images/534413974788243456/Dnfeg_tE_normal.jpeg
@AzraBihorac nice! to year you are using ultrasound! feels like it can be helpful for early severe intrinsic AKI #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
QFT @dr_nikhilshah: T0 Stages are for non nephrologists! They are a marker to get the nephro involved before everything goes south! #nephjc
azrabihorac
https://pbs.twimg.com/profile_images/530502120009502720/WH1UnphS_normal.jpeg
#nephjc I will be publishing our clinal,protocol for "kidney assessment " on ICU admission
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
Granular casts #nephjc http://t.co/eiElcerLHl
wittykidney
https://pbs.twimg.com/profile_images/553936695637606401/GNV7JM5x_normal.jpeg
@doc_faubel @AzraBihorac how ultrasound is helpful? #nephjc
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
RT @kidney_boy: Granular casts #nephjc http://t.co/eiElcerLHl
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
sounds interesting -> @AzraBihorac: #nephjc I will be publishing our clinal,protocol for "kidney assessment " on ICU admission
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
Awesome pic: @kidney_boy: Granular casts #nephjc http://t.co/qgHnwt8Ngu
azrabihorac
https://pbs.twimg.com/profile_images/530502120009502720/WH1UnphS_normal.jpeg
@doc_faubel #nephjc Sarah your review on US is incredible!
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
RT @AzraBihorac: #nephjc I will be publishing our clinal,protocol for "kidney assessment " on ICU admission
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
@AzraBihorac @doc_faubel Care to share the link with us? #nephjc
k2optimist
https://pbs.twimg.com/profile_images/288959270/Brains_normal.jpg
RT @edgarvlermamd: The Kidney Injury continuum #Nephpearls #NephJC http://t.co/7fPkoLIcat http://t.co/nfOwz81kxH
doc_faubel
https://pbs.twimg.com/profile_images/534413974788243456/Dnfeg_tE_normal.jpeg
@NephJC @AzraBihorac @doc_faubel http://t.co/SSXtS4U0fK #nephjc
hecmagsmd
https://pbs.twimg.com/profile_images/555936314122842113/5A3PrkXC_normal.jpeg
Renal US is not for everyone with AKI. Will do only if Hx of hydronephrosis, kidney stones, BPH, hx of malignancy... #nephjc
azrabihorac
https://pbs.twimg.com/profile_images/530502120009502720/WH1UnphS_normal.jpeg
#nephjc I propose a new paradigm. I think we have many very good tools but we lack timely and standrdized approach
edgarvlermamd
https://pbs.twimg.com/profile_images/2297302029/image_normal.jpg
Why we need AKI BIOMARKERS? #Nephpearls #NephJC http://t.co/N9QNOuw4UI http://t.co/emG3m3XzTF
dr_nikhilshah
https://pbs.twimg.com/profile_images/801651738524598272/d9uOVZ_9_normal.jpg
AKI in ICU and AKI in Non ICU Ward and AKI in Out Patient are 3 different entities. Dealt differently. #nephjc
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
I think this is Faubel's U/S article: http://t.co/pmn5Qey0PC #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
T0: looks like staging more imp in ICU, for non-nephrons. Prognostication >> diagnosis for nephrons. Lets move on .. #nephjc
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
http://t.co/TGebhY4SxP Renal relevant radiology: use of ultrasonography in patients with AKI. @doc_faubel #nephjc
franloachamin
https://pbs.twimg.com/profile_images/447648196031152128/iSjgnGBC_normal.jpeg
RT @NephJC: AKI staging redux from @goKDIGO for tonight's #Nephjc http://t.co/zd4zAIhqX4
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
Thanks -> @kidney_boy: I think this is Faubel's U/S article: http://t.co/A0idZ5n4yv #nephjc
hecmagsmd
https://pbs.twimg.com/profile_images/555936314122842113/5A3PrkXC_normal.jpeg
RT @AzraBihorac: #nephjc I propose a new paradigm. I think we have many very good tools but we lack timely and standrdized approach
azrabihorac
https://pbs.twimg.com/profile_images/530502120009502720/WH1UnphS_normal.jpeg
@dr_nikhilshah #nephjc agree,! Geography matters! Look for context of your patient hospital entry point.
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
RT @dr_nikhilshah: AKI in ICU and AKI in Non ICU Ward and AKI in Out Patient are 3 different entities. Dealt differently. #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
T1: Lets look closely at the studies: Discovery (identification) Sapphire (validation) Topaz (external validation) #nephjc
doc_faubel
https://pbs.twimg.com/profile_images/534413974788243456/Dnfeg_tE_normal.jpeg
@kidney_boy thanks joel! I was excited to find the link and forgot to type anything else #nephjc
hecmagsmd
https://pbs.twimg.com/profile_images/555936314122842113/5A3PrkXC_normal.jpeg
RT @dr_nikhilshah: AKI in ICU and AKI in Non ICU Ward and AKI in Out Patient are 3 different entities. Dealt differently. #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
RT @AzraBihorac: #nephjc I propose a new paradigm. I think we have many very good tools but we lack timely and standrdized approach
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
T1: the authors list for SAPPHIRE reads like a who's who of ICU/Neph researchers #nephjc http://t.co/x3cgibpd9V
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
@doc_faubel I'm your wing man. #nephjc
edgarvlermamd
https://pbs.twimg.com/profile_images/2297302029/image_normal.jpg
Factors affecting creatinine in AKI #Nephpearls #NephJC http://t.co/N9QNOuw4UI http://t.co/F6fJt0ZbkX
kidney_md
https://pbs.twimg.com/profile_images/2773691458/7bef40f1562a551baf2894a1a08c5cff_normal.jpeg
biomarker h/o AMI vs AKI http://t.co/6N5D41NyFA #nephJC http://t.co/mMb2FfhavX
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
T0 I always stop the presentation and ask the fellow/resident how the PT was admitted... from ER/clinic/home... #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
T1: Discovery and Sapphire paper figure 1: http://t.co/ml5FfQ52cZ #nephjc http://t.co/Pt4zV3NhOJ
dr_nikhilshah
https://pbs.twimg.com/profile_images/801651738524598272/d9uOVZ_9_normal.jpg
RT @Nephro_Sparks: T0 I always stop the presentation and ask the fellow/resident how the PT was admitted... from ER/clinic/home... #nephjc
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
T0 the key to finding prognosis is in the history not the lab findings #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
RT @Nephro_Sparks: T0 I always stop the presentation and ask the fellow/resident how the PT was admitted... from ER/clinic/home... #nephjc
wittykidney
https://pbs.twimg.com/profile_images/553936695637606401/GNV7JM5x_normal.jpeg
RT @Nephro_Sparks T0 the key to finding prognosis is in the history not the lab findings #nephjc #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
Words of the wise! @Nephro_Sparks: T0 the key to finding prognosis is in the history not the lab findings #nephjc
hecmagsmd
https://pbs.twimg.com/profile_images/555936314122842113/5A3PrkXC_normal.jpeg
RT @Nephro_Sparks: T0 the key to finding prognosis is in the history not the lab findings #nephjc
othinkagain
https://pbs.twimg.com/profile_images/651120651030298624/j6iBJAu8_normal.jpg
RT @kidney_md: biomarker h/o AMI vs AKI http://t.co/6N5D41NyFA #nephJC http://t.co/mMb2FfhavX
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
T1: How do you determine the best biomarkers? Why two and not three? #nephjc
alinspring
https://pbs.twimg.com/profile_images/833468038259277824/AQIUCn8f_normal.jpg
RT @NephJC: T1: Discovery and Sapphire paper figure 1: http://t.co/ml5FfQ52cZ #nephjc http://t.co/Pt4zV3NhOJ
langoteamit
https://pbs.twimg.com/profile_images/618996490665488384/RYS5ZWFm_normal.jpg
Completely agree,i spend > time in history RT @Nephro_Sparks: T0 the key to finding prognosis is in the history not the lab findings #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
T1: so first they 'discovered' candidate molecules, then SAPPHIRE was validation on a larger cohort #Nephjc
alinspring
https://pbs.twimg.com/profile_images/833468038259277824/AQIUCn8f_normal.jpg
RT @Nephro_Sparks: T0 the key to finding prognosis is in the history not the lab findings #nephjc
jaykoyner
https://pbs.twimg.com/profile_images/651800506654945280/T_jfv8F__normal.jpg
community acquired AKI is different than hospital acquired and requires a different work up and maybe different biomarkers #nephjc
hswapnil
https://pbs.twimg.com/profile_images/730502747754139649/hP6Q9DDQ_normal.jpg
RT @NephJC: T1: Discovery and Sapphire paper figure 1: http://t.co/ml5FfQ52cZ #nephjc http://t.co/Pt4zV3NhOJ
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
Same with the diagnosis RT @Nephro_Sparks: T0 the key to finding prognosis is in the history not the lab findings #nephjc
hswapnil
https://pbs.twimg.com/profile_images/730502747754139649/hP6Q9DDQ_normal.jpg
RT @NephJC: T1: so first they 'discovered' candidate molecules, then SAPPHIRE was validation on a larger cohort #Nephjc
doc_faubel
https://pbs.twimg.com/profile_images/534413974788243456/Dnfeg_tE_normal.jpeg
T1: Figure 1 contains best part of the design which is to identify "best two markers" #nephjc
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
They had three different cohorts shouldn't it be a good mix of AKI etiologies? #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
T1: Discovery: IGFBP-7 and TIMP blew away NGAL and KIM-1! #nephjc http://t.co/4xLygY2rkM
dr_nikhilshah
https://pbs.twimg.com/profile_images/801651738524598272/d9uOVZ_9_normal.jpg
Diagnosis = History, Prognosis = Clinical background and Response, Biomarkers = ?benefit #nephjc
edgarvlermamd
https://pbs.twimg.com/profile_images/2297302029/image_normal.jpg
New entities within the AKI spectrum #Nephpearls #NephJC http://t.co/YOq6UlDExE http://t.co/r8gMdmIqJG
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
T1: but all critically ill @kidney_boy: They had three different cohorts shouldn't it be a good mix of AKI etiologies? #nephjc
franloachamin
https://pbs.twimg.com/profile_images/447648196031152128/iSjgnGBC_normal.jpeg
RT @edgarvlermamd: Factors affecting creatinine in AKI #Nephpearls #NephJC http://t.co/N9QNOuw4UI http://t.co/F6fJt0ZbkX
azrabihorac
https://pbs.twimg.com/profile_images/530502120009502720/WH1UnphS_normal.jpeg
@dr_nikhilshah #nephjc first head to head comparison between all biomarkers including comparison of performance re: ckd
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
T1: more on how IGFBP7/TIMP2 blows away NGAL and KIM-1: figure 2 #nephjc http://t.co/Rjio3TXcSh
dr_nikhilshah
https://pbs.twimg.com/profile_images/801651738524598272/d9uOVZ_9_normal.jpg
RT @AzraBihorac: @dr_nikhilshah #nephjc first head to head comparison between all biomarkers including comparison of performance re: ckd
hswapnil
https://pbs.twimg.com/profile_images/730502747754139649/hP6Q9DDQ_normal.jpg
T1: #NephSAP review from 2006 is excellent (and free access link) - but NGAL/kim1/etc - no IGFBP or TIMP! http://t.co/5U7T9WgBai #nephjc
jaykoyner
https://pbs.twimg.com/profile_images/651800506654945280/T_jfv8F__normal.jpg
@edgarvlermamd right edgar combining functional markers and structural markers will be key and help with risk stratification #nephjc
langoteamit
https://pbs.twimg.com/profile_images/618996490665488384/RYS5ZWFm_normal.jpg
@kidney_boy It did not hv tropical ds. AKI in western world is > hosp acquired #nephjc
hswapnil
https://pbs.twimg.com/profile_images/730502747754139649/hP6Q9DDQ_normal.jpg
T1: From #nephSAP review - it was all NGAL and KIM 1 et al! I did think NGAL was the ONE.. #nephJC http://t.co/nQUmE17eHD
idpharmprof
https://pbs.twimg.com/profile_images/1162532615/SLD_Head_normal.jpg
RT @edgarvlermamd: Why we need AKI BIOMARKERS? #Nephpearls #NephJC http://t.co/N9QNOuw4UI http://t.co/emG3m3XzTF
kidney_boy
https://pbs.twimg.com/profile_images/817201108808593408/BLKlnv3k_normal.jpg
@AzraBihorac Looks like AUC of [TIMP-2]•[IGFBP7] was not much better than TIMP-2. Why the combination? #NephJC
nephro_sparks
https://pbs.twimg.com/profile_images/552496649495273472/UA46V1Ye_normal.jpeg
T1- This looks like a great design to me. With all the focus on NGAL and KIM 1 = surprised #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
T1: outcome for diagnosis: - stage 2/3 AKI per @goKDIGO #nephjc http://t.co/S6fvoXmriv
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
T1: secondary outcome also also MAKE30: the composite of death/RRT/persistent AKI (200% elevation creatinine) at 30 days #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
RT @Nephro_Sparks: T1- This looks like a great design to me. With all the focus on NGAL and KIM 1 = surprised #nephjc
jaykoyner
https://pbs.twimg.com/profile_images/651800506654945280/T_jfv8F__normal.jpg
@hswapnil at some point in time someone thought LDH and CK were the one's for AMI .... NGAL still has tremendous value #nephjc
hecmagsmd
https://pbs.twimg.com/profile_images/555936314122842113/5A3PrkXC_normal.jpeg
RT @edgarvlermamd: Why we need AKI BIOMARKERS? #Nephpearls #NephJC http://t.co/mi3HeufSog http://t.co/P83u4RkPzp
pednephrol
https://pbs.twimg.com/profile_images/1744924654/RETRATO_MST_2012_JAN_normal.jpg
RT @NephJC: T1: Discovery: IGFBP-7 and TIMP blew away NGAL and KIM-1! #nephjc http://t.co/4xLygY2rkM
pednephrol
https://pbs.twimg.com/profile_images/1744924654/RETRATO_MST_2012_JAN_normal.jpg
RT @NephJC: T1: more on how IGFBP7/TIMP2 blows away NGAL and KIM-1: figure 2 #nephjc http://t.co/Rjio3TXcSh
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
Skepticism> @jaykoyner: at some point in time someone thought LDH and CK were the one's for AMI NGAL still has tremendous value #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
T1: #Nephrocheck = simple multiplication of the two markers [TIMP-2]·[IGFBP7]. Decision based on Discovery it seems #nephJc
azrabihorac
https://pbs.twimg.com/profile_images/530502120009502720/WH1UnphS_normal.jpeg
@kidney_boy #nephjc they have different timing of appearance and bring two complementary biological mechanism
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
T1: lastly, TOPAZ was external validation in a different cohort All well and good #nephjc
langoteamit
https://pbs.twimg.com/profile_images/618996490665488384/RYS5ZWFm_normal.jpg
RT @AzraBihorac: @kidney_boy #nephjc they have different timing of appearance and bring two complementary biological mechanism
edgarvlermamd
https://pbs.twimg.com/profile_images/2297302029/image_normal.jpg
Spectrum of injury in AKI #Nephpearls #NephJC http://t.co/43NC77a3Lj http://t.co/ua0lFwKTW8
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
Synergistic? @AzraBihorac: @kidney_boy #nephjc they have different timing of appearance and bring two complementary biological mechanism
hecmagsmd
https://pbs.twimg.com/profile_images/555936314122842113/5A3PrkXC_normal.jpeg
RT @AzraBihorac: @kidney_boy #nephjc they have different timing of appearance and bring two complementary biological mechanism
azrabihorac
https://pbs.twimg.com/profile_images/530502120009502720/WH1UnphS_normal.jpeg
@NephJC #nephjc FIRST AKI study with clinical validation of AKI
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
T1: Paper 2 TOPAZ author list. Some (not all) names from SAPPHIRE #nephjc http://t.co/RTzYajL9Cn
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
T1: TOPAZ fig 1: critically ill 400 patients #nephJC http://t.co/D4x1vhyBkR
jaykoyner
https://pbs.twimg.com/profile_images/651800506654945280/T_jfv8F__normal.jpg
@NephJC NGAL performed OK in this cohort - but has been shown to predict clinically meaningful endpoints in several cohorts #nephjc
nephjc
https://pbs.twimg.com/profile_images/662057138684952577/2ZnKmQ3p_normal.png
T1: TOPAZ fig 2: IGFBP7*TIMP2 much higher in AKI than non AKI #nephJC. Similar to SAPPHIRE http://t.co/sNltvj8tGc
hecmagsmd
https://pbs.twimg.com/profile_images/555936314122842113/5A3PrkXC_normal.jpeg
RT @NephJC: T1: Discovery: IGFBP-7 and TIMP blew away NGAL and KIM-1! #nephjc http://t.co/4xLygY2rkM
azrabihorac
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@NephJC #nephjc meant to say Clinical adjudication of AKI diagnosis.
wittykidney
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@AzraBihorac @kidney_boy does the agents that arrest cell growth, alter these levels, in addition to ischemic injury? #nephjc
nephjc
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T1: why these molecules? This graphic is fig 5 from SAPPHIRE. Everyone convinced? #nephjc http://t.co/zCdEiX2FOh
kidney_boy
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What does that mean. What is the alternative? RT @AzraBihorac: #nephjc FIRST AKI study with clinical validation of AKI
hswapnil
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T1: shameless plug: @eAJKD piece on IGFs IGFBPs and kidney: http://t.co/wUaGKA00fM #Nephjc
edgarvlermamd
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Pathophysiology and Cellular mechanisms in AKI #Nephpearls #NephJC http://t.co/7fPkoLIcat http://t.co/2LnDUvxUq6
nephjc
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RT @edgarvlermamd: Pathophysiology and Cellular mechanisms in AKI #Nephpearls #NephJC http://t.co/7fPkoLIcat http://t.co/2LnDUvxUq6
azrabihorac
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@kidney_boy #nephjc AKI diagnosis was not only made using change in cr and KdIGo but was adjudicated by independent nephrologist
jaykoyner
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topaz done exclusively in the US thats why the author list is similar but not 100% same vs Sapphire #nephjc
nephjc
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RT @AzraBihorac: AKI diagnosis was not only made using change in cr and KdIGo but was adjudicated by independent nephrologist #nephjc
hswapnil
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T1: is this just correlation not causation? Strictly speaking need Hill's criteria satisfied #nephJC http://t.co/xB51f9CU2F
hswapnil
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RT @jaykoyner: @hswapnil at some point in time someone thought LDH and CK were the one's for AMI .... NGAL still has tremendous value #nephjc
kidney_boy
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@AzraBihorac who then just looked at Cr and UO? Or just a chart? Or did they examine the patient? #nephjc
doc_faubel
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@AzraBihorac @kidney_boy adjudication of any clinical diagnosis in a study is gold std to help get FDA approval for your test/drug #nephjc
azrabihorac
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@kidney_boy #nephjc everything available to that point
nephjc
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T1 before we go to T2 and the ROC business, is everyone happy with the data so far? Guess @kidney_boy has doubts! #nephjc
langoteamit
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@AzraBihorac How many fullfilled primary endpt after 24 hours ? #nephjc
k2optimist
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RT @hswapnil: T1: is this just correlation not causation? Strictly speaking need Hill's criteria satisfied #nephJC http://t.co/xB51f9CU2F
nephjc
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RT @jaykoyner: @NephJC NGAL performed OK in this cohort - but has been shown to predict clinically meaningful endpoints in several cohorts #nephjc
kidney_boy
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Reading the caption to figure 5 tells me we know way too much about tubular cells. Wow. #nephjc
nephjc
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Lot of speculation in there, rt? @kidney_boy: Reading the caption to figure 5 tells me we know way too much about tubular cells. Wow #nephjc
doc_faubel
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@LangoteAmit @AzraBihorac 14% had AKI in sapphire; 17% in Topaz #nephjc
nephjc
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T2: let's now dive into sensitivities, specificities and ROCs #nephjc http://t.co/HisFBOtz5C
hswapnil
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T2: Everything you wanted to know about ROC and Likelihood ratios )but didn't know whom to ask) #OpenAccess http://t.co/K8qOIeUyO0 #nephjc
azrabihorac
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@kidney_boy #nephjc we are obsessed with tubular cells as a discipline....
kidney_md
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Key Concepts and Limitations of Statistical Methods for Evaluating Biomarkers of Kidney Disease #nephJC http://t.co/mQbLc9wqlI
dr_nikhilshah
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RT @hswapnil: T2: Everything you wanted to know about ROC and Likelihood ratios )but didn't know whom to ask) #OpenAccess http://t.co/K8qOIeUyO0 #nephjc
nephjc
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T2: ROC from TOPAZ: really sens at >0.3, specific at >2.0 #nephjc http://t.co/xRMT8KVaTB
nephjc
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RT @kidney_md: Key Concepts and Limitations of Statistical Methods for Evaluating Biomarkers of Kidney Disease #nephJC http://t.co/mQbLc9wqlI
nephjc
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@kidney_md nice find. Chirag parikh from Yale is a strong NGAL supporter.... #nephjc
doc_faubel
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T2: so what cut off would be best for an intervention in a clinical trial? #nephjc
nephjc
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T2: more data from the #nephrocheck package insert http://t.co/N80O0zO9n9 #nephJC http://t.co/NpBpQ85dvW
nephjc
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T2: granular data from package insert for SAPPHIRE. > 90% sens; ~ 50% spec at level > 0.3 #nephJC http://t.co/oHvG6CSljl
nephjc
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T2: more granular data from package insert for SAPPHIRE study#nephjc http://t.co/zvAoUIYMbR
cmapit
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RT @hswapnil: T2: Everything you wanted to know about ROC and Likelihood ratios )but didn't know whom to ask) #OpenAccess http://t.co/K8qOIeUyO0 #nephjc
azrabihorac
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@doc_faubel #nephjc Sarah I think it would Depend on risk benefit ratio of intervention
hecmagsmd
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RT @hswapnil: T2: Everything you wanted to know about ROC and Likelihood ratios )but didn't know whom to ask) #OpenAccess http://t.co/K8qOIeUyO0 #nephjc
nephjc
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T2: from package insert for TOPAZ Sens 76% at >0.3? Am I reading that right @AzraBihorac? #nephJC http://t.co/rWJiNq01nU
for_content
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RT @hswapnil: T2: Everything you wanted to know about ROC and Likelihood ratios )but didn't know whom to ask) #OpenAccess http://t.co/K8qOIeUyO0 #nephjc
kidney_boy
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@NephJC OMG Swapnil was reading package inserts today! Give him a metal! #nephjc
jaykoyner
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@AzraBihorac @doc_faubel #nephjc agreed depends on the intervention - when we did lasix challenge we looked at 0.3 (low risk)
kidney_boy
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@jaykoyner @AzraBihorac @doc_faubel what's lasix challenge? #nephjc
azrabihorac
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#nephjc dr. Chaka just published article on it
jaykoyner
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but if your drug inhibits p53 and carries high risk you likely want a higher cutoff the 2.0 #nephjc
nephjc
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BTW - these studies have been sponsored by #Nephrocheck maker, Astute: http://t.co/2ttyyIHmgc #NephJC
kidney_md
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Summary of traditional and novel measures (Parikh) http://t.co/mQbLc9wqlI #NephJC http://t.co/9UOsZDGt96
nephjc
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RT @jaykoyner: @AzraBihorac @doc_faubel #nephjc agreed depends on the intervention - when we did lasix challenge we looked at 0.3 (low risk)
kidney_boy
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@jaykoyner but 0.3 is not risk, it means you are going to collect everyone with AKI, at the expense of collecting those without AKI #nephjc
langoteamit
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@kidney_md Cant read ?? #nephjc
nephjc
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RT @kidney_md: Summary of traditional and novel measures (Parikh) http://t.co/mQbLc9wqlI #NephJC http://t.co/9UOsZDGt96
jaykoyner
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@AzraBihorac #nephjc http://t.co/H6XrRY7sQ3 this is the paper we just published - self promotion ok here?
kidney_boy
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0.3 will dilute any intervention with people who don't get AKI. Should go 0.2 for treatment #nephjc
edgarvlermamd
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Biomarker performance in detecting AKI from @jaykoyner @KidneyNews #Nephpearls #NephJC http://t.co/5tD7VidMkm http://t.co/1mpyXT0tvz
hswapnil
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T2: Some more on biomarkers and ROC from the #nephSAP review #nephJC http://t.co/9GBZ3yMLaE
othinkagain
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RT @hswapnil: T2: Everything you wanted to know about ROC and Likelihood ratios )but didn't know whom to ask) #OpenAccess http://t.co/K8qOIeUyO0 #nephjc
kidney_boy
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I mean 0.3 will dilute any intervention with people who don't get AKI. Should go 2.0 for treatment #nephjc
nephjc
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RT @edgarvlermamd: Biomarker performance in detecting AKI from @jaykoyner @KidneyNews #Nephpearls #NephJC http://t.co/5tD7VidMkm http://t.co/1mpyXT0tvz
hecmagsmd
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RT @jaykoyner: @AzraBihorac #nephjc http://t.co/H6XrRY7sQ3 this is the paper we just published - self promotion ok here?
nephjc